报告题目：Computational Systems Biology of Cellular Rhythms

报告人： Albert Goldbeter

       Faculty of Sciences, Université Libre de Bruxelles (ULB), Brussels, Belgium

        http://www.ulb.ac.be/sciences/utc/

报告时间：10:00 am, May 4th(Wednesday)

报告地点：Room 1801, East Guanghua Tower

摘要：

Sustained oscillations arise in genetic and metabolic networks as 

a result of various modes of cellular regulation. In view of t

he large number of variables involved and of the complexity of 

feedback processes that generate oscillations, mathematical models a

re needed to investigate the nonlinear dynamics of biological rhythms. 

The presentation will focus on two major cellular rhythms: circadian clocks, w

hich occur spontaneously in most organisms with a period close to 24h, and the c

ell cycle. Based on experimental observations, mathematical models for circadian 

clocks predict the occurrence of sustained oscillations corresponding to the e

volution toward a limit cycle. Chaos can also occur in these models, either i

n autonomous conditions or as a result of periodic forcing by light-dark cycles. 

A model for circadian rhythms in mammals permits to investigate the dynamical 

bases of physiological disorders of the sleep-wake cycle in humans. In regard 

to the cell cycle, models of increasing complexity have been proposed, first 

for the embryonic cell cycle, and, subsequently, for the yeast and mammalian c

ell cycles. The model for the mammalian cell cycle shows 

hat it behaves as a self-sustained oscillator.