| 主 题 | Quantifying Neuronal Network Dynamics through Coarse-Grained Event-Trees |
| 报告人 | David W. McLaughlin (美国纽约大学教务长，柯朗研究所教授，美国国家科学院院士) |
| 时 间 | 2008年6月13日（星期五） 下午15：30—16：20 |
| 地 点 | 复旦大学光华东辅楼101室 |
| 简 介 | 主持人：李大潜院士 Joint with Aaditya V. Rangan, David Cai 摘要: Animals process information about many stimulus features simultaneously, swiftly (in a few 100 ms), and robustly (even when individual neurons do not themselves respond reliably). When the brain carries, codes, and certainly when it decodes information, it must do so through some coarse-grained projection mechanism. How can a projection retain information about network dynamics which covers multiple features, swiftly and robustly? Here, via a coarse-grained projection to event-trees, and to the event-chains which comprise these trees, we propose a new method of characterizing dynamical information of neuronal networks using a statistical collection of spatial-temporal sequences of relevant physiological observables (such as sequences of spiking multiple neurons). We demonstrate, through idealized point neuron simulations in small networks, that this new event-tree analysis can reveal, with high reliability, information about multiple stimulus features within short realistic observation times. Then, with a large-scale realistic computational model of V1, we show that coarse-grained event trees contain sufficient information, again over short observation times, for fine discrimination of orientation - with results consistent with recent experimental observation. |
